Saints have promoted youngsters Andre Savelio and Lewis Charnock into their Super League squad in the absence of seven first-choice players through injury or suspension.
Lance Hohaia is expected to resume at stand-off after pulling out of last Sunday’s game with a knee problem while Mark Percival is set to return at centre and prop Mose Masoe makes his first start.
Leeds coach Brian McDermott has recalled Kevin Sinfield, Jamie Peacock and Tom Briscoe after resting them for the win over London Broncos.
Second-rower Brett Delaney returns after recovering from a leg injury and centre Joel Moon will also be back if he passes a late fitness test on his hamstring.
Forwards Chris Clarkson and Ryan Bailey are among the players to miss out.
The referee is Richard Silverwood.