James Roby and Ben Barba have been named on the three-man shortlist for the Steve Prescott Man of Steel 2018.
Wigan back-rower John Bateman is the third nominee.
North Queensland Cowboys-bound full-back Barba, 29, has been a stand-out player in the Super League this season, top scoring with 26 tries in 21 Saints appearances.
Skipper Roby, 32, has led Saints to the League Leaders' Shield and the Super 8s semis with four tries in 22 matches.
England international Bateman, 24, has four tries in 25 Warriors games. The former Bradford player, who will join National Rugby League side Canberra Raiders on a three-year deal for 2019, is in the top 10 for tackle-busts and metres made.
No club has contributed more winners than Wigan's 11, while Saints have had eight winners since the award was inaugurated in 1977.
Ex-England, Hull FC, Wakefield and St Helens full-back Steve Prescott, who died in 2013 after a brave battle with stomach cancer, had his name added to the award in 2014.
Only three players have won multiple awards; Wigan's Ellery Hanley and Andy Farrell plus Saints' Paul Sculthorpe, and Roby - a winner in 2007 - would join that elite group if he were to claim the prize.
In addition to the main award, Castleford Tigers half-back Jacob Trueman, St Helens prop Matty Lees and Leeds Rhinos full-back Jack Walker have been confirmed as the nominees for the Young Player of the Year.
Both of these awards, along with the newly-introduced Woman of Steel award and others including Coach, Club and Foundation of the Year prizes, will be presented at an event in Manchester on Monday, October 8.