A number of entrepreneurs are believed to be poised to make a bid for the old Tyrers site, the Reporter understands.
A source close to negotiations said talks were ongoing but it unlikely the site would remain empty for long.
There has been speculation budget fashion retailer Primark could make a pitch for a move into St Helens town centre, with Tyrers site being an obvious target.
However, it is unclear whether the Tyrers building is big enough for Primark, who have stores in neighbouring Wigan and Warrington.
Meanwhile, it is thought TJ Hughes is getting closer to opening in the Hardshaw Centre.