Saints will face Warrington as they bid to make the first Challenge Cup final played at the rebuilt Wembley Stadium.
In Wednesday's draw, Daniel Anderson's side were hand a home draw against their local rivals while Wigan drew Harlequins.
Hull entertain Catalans Dragons and Bradford will take on Huddersfield at Odsal in the remaining ties.
So the mouth-watering prospect of a Saints v Wigan Wembley final is still alive.
The cup holders have a near perfect Super League record against Warrington and will be favourites to reach the semi finals.
Coach Daniel Anderson said on the eve of the draw: "Everybody keeps telling me how special Wembley is but I have never been to the place to be honest.
"I know it has cost a great deal of money to rebuild and always seems to be on television but I also know the Challenge Cup is a very unique competition.
"Down Under, we don't have knockout cups and I think you'll find a lot of players from the southern hemisphere quite enjoy the competition.
"People are nervous before cup games and its great to be in any contest of this kind so we are obviously delighted at moving a step closer to the final again."
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Weather for St Helens
Thursday 20 June 2013
Temperature: 13 C to 18 C
Wind Speed: 12 mph
Wind direction: South east
Temperature: 13 C to 17 C
Wind Speed: 15 mph
Wind direction: West