The town centre Burton and Dorothy Perkins store is to close - but store bosses say hope to re-deploy affected staff to other stores.
The clothes shop, located on the corner of Church Street and Bridge Street, is to shut its doors for the final time this Saturday (June 14).
Posters have been placed in the window to remind customers that Burton and Dorothy Perkins - popular brands which cater for men and women respectively - are both still represented at Ravenhead Retail Park.
Dorothy Perkins also has a clothing section within the BHS store in Church Square.
But this still represents another hammer blow to the high street in St Helens following the closure of the likes of WHSmith and Woolworths in recent years.
Internet shopping, competition from city centres and out-of-town shopping centres, a perceived lack of variety and the cost of parking have all been cited as reasons why town centres like St Helens are struggling.
St Helens Council has already vowed to invest £1m to bring about improvements in the town centre, to introduce free parking on Saturdays and appoint a taskforce to review the town centre’s future.
A spokesman for the Arcadia Group, which runs Burton and Dorothy Perkins, said; “We are always looking at how to shape our store portfolio, investing in flagship stores, and increasing our presence online. When leases expire that we do not renew, we endeavour to re-deploy staff.”